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ProMED翻訳情報(218回) ~中国における人狂犬病の経口感染に関する意見~




Date: Thu 26 Sep 2013

From: Charles Rupprecht <charles_rupprecht@yahoo.com> [edited]


The report of a another human rabies death in rural China is quite tragic, as is every case of this preventable disease. However, there are multiple points that were missed in the report as to several basic facts.




Rabies is not just “a 3rd world” problem. This zoonosis perpetuates itself on all inhabited continents with few exceptions. Clearly, human rabies prophylaxis is affordable, particularly through the use of dose saving multi-site intra-dermal vaccination by modern human tissue culture biologics.




Mass dog vaccination, not culling, is the safe, humane, and cost-effective method for the elimination of canine rabies on a global level. In addition, although bites are the most common means of infection, mucosal contamination is also a method for viral transmission. Oral lesions are not needed. Lyssaviruses can utilize receptors in the oral-pharygneal(pharyngeal) cavity (not the lower GI, given the harsh acidic environment present in the stomach of carnivores). Such pathobiological elements are the basis for the oral vaccination of free-ranging carnivores, which has led to the prevention and control of wildlife, particularly in Western Europe and North America.

Moreover, proper public education of children, improved social media outlets for health communications, renewed advocacy, and local community engagement are necessary, particularly given the recognition of World Rabies Day later this month, on Sat 28 Sep 2013.



C.E. Rupprecht VMD, MS, PhD

Director of Research

The Global Alliance For Rabies Control




[ProMED-mail thank Charles Ruprecht for these comments on the cases of a Chinese father who contracted rabies by attempting to interrupt transmission of the virus by sucking fluid from the child’s lesion. In particular, this moderator thanks Charles Rupprecht for the information that oral lesions are not a requirement for transmission of lyssaviruses, which are able to attach to receptors in the oral-pharygneal cavity (but not the lower GI, given the harsh acidic environment present in the stomach of carnivores).


ProMED-mailは、Charles Ruprechtの、中国人の父親の(狂犬病罹患の)ケースに関する上記のコメントに対し感謝する。父親は、子どもの傷口から体液を吸うことによりウイルスの感染を防ごうとして、狂犬病に罹った。特に、今回のモデレーターは、リッサウイルスは口腔から咽喉腔に有る受容体に接着することが出来るので、感染に口腔内の傷を必要としないと言う情報を提供してくれたCharles Ruprechtに感謝する。( )内は上記参照。


ProMED-mail welcomes this opportunity to draw attention to the fact that World Rabies Day occurs on Sat 28 Sep 2013. – Mod.CP

ProMED-mail は、2013年9月28日土曜日が世界狂犬病の日であることに注意を惹きつけるこの機会を歓迎する。